Abstract Background Urinary tract infections (UTIs) are one of the most common infections in primary care.Previous research showed that GPs find it challenging to diagnose UTIs and frequently divert from guidelines leading to unwarranted antibiotic prescriptions and inefficient use of diagnostics such as urinary cultures.We hypothesise that managem

Large preclinical evidence shows that exposure to social defeat (SD) increases vulnerability to drug abuse, increasing the consumption of ethanol.However, not all subjects are equally affected by the changes induced by stress.Previous reports have evidenced that the resilient phenotype to depressive-like behaviors after SD is associated with the re

Clostridioides difficile infection (CDI) worsens inflammatory bowel disease (IBD) prognosis.While fecal microbiota transplantation (FMT) is effective for refractory or recurrent CDI (rrCDI), comparative success rates between IBD and non-IBD patients are scarce.This study addresses this gap.A retrospective cohort study was conducted at Chang Gung Me

Avian influenza virus (AIV) can directly cross species barriers and infect humans with high fatality.Using machine learning methods, the present paper scores the amino acid mutations and predicts interspecies transmission.Initially, 183 signature positions in 11 viral proteins were screened by the scores of five amino acid factors and their random

Amyloids are fibrous proteins aggregated into toxic forms that are implicated in several chronic disorders.More than 30 diseases show deposition of fibrous amyloid proteins associated with cell Plastic Shelving Kits loss and degeneration in the affected tissues.Evidence demonstrates that amyloid diseases result from protein aggregation or impaired